Decomposition of the average binding energy of the highest populated tetrameric oligomers for rIAPP and hIAPP.

Evdw, and Eelec are the van der Waals and electrostatic binding terms. Egb and Esurf are the solvation energies of polar and nonpolar residues, calculated by Amber 9 using the Generalized Born model. Ep and Enp are the sums of polar energy (Eelec+Egb) and nonpolar energy components (Evdw+Esurf), respectively. Etotal is the sum of Ep and Enp. Error bars represent standard deviations over 100 configurations extracted from the global minimum indicated by the free energy landscapes.