Differentially expressed genes in Mettl3-deficient livers compared to control livers

Liver-specific deficiency of Mettl3 causes liver injury. By performing RNA sequencing (RNA-seq) analysis on the Mettl3-deficient versus control livers, we identified the potential target genes that were closely associated with the liver phenotype in liver-specific Mettl3 knockout mice. RNA-seq analysis revealed extensive metabolic reprogramming in Mettl3-deficient livers. These results demonstrated that Mettl3 coordinates metabolic homeostasis and functional maturation during postnatal liver development. mRNA profiles of 3 wild type (WT) and 3 Mettl3-deficient liversMettl3的肝脏特异性缺失会引发肝损伤。通过对Mettl3缺失型肝脏与对照肝脏开展RNA测序（RNA-seq）分析，我们在肝脏特异性Mettl3敲除小鼠中鉴定出了与肝脏表型密切相关的潜在靶基因。RNA-seq分析结果显示，Mettl3缺失型肝脏中存在广泛的代谢重编程。上述研究结果表明，Mettl3在出生后肝脏发育过程中可协调代谢稳态与功能成熟。本数据集包含3份野生型（WT）与3份Mettl3缺失型肝脏的mRNA表达谱。