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Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

ChEBI2013-11-20 更新2026-07-21 收录

基因敲低实验

RNA剪接调控

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-52493 数据链接链接失效反馈

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Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

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创建时间：

2013-11-20

剪接保真度

RNA剪接调控

Fidelity of 3´-splice site (3´SS) selection by the spliceosome is critical for proper gene expression but is a daunting task considering the low complexity of the 3´SS consensus YAG. Here we show that

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CHIP knockdown effect on breast cancer cell line

乳腺癌基因功能

基因敲低实验

CHIP knockdown effect on breast cancer cell line

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The zinc finger domains in U2AF26 and U2AF35 have diverse functionalities including a role in controlling translation

RNA剪接调控

翻译控制

Recent work has associated point mutations in both zinc fingers (ZnF) of the spliceosome component U2AF35 with malignant transformation. However, surprisingly little is known about the functionality o

NIAID Data Ecosystem30

ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing. ELAV/Hu RNA binding proteins determine multiple programs of neural alternative splicing

RNA剪接调控

神经元mRNA处理

ELAV/Hu factors are conserved RNA binding proteins that play diverse roles in mRNA processing and regulation. The founding member, Drosophila Elav, was recognized as a vital neural factor 35 years ago

NIAID Data Ecosystem40

Glucose dissociates DDX21 dimers to regulate mRNA processing and promote epidermal differentiation (RNA-Seq II)

RNA剪接调控

表皮细胞分化

Glucose is an important cellular energy source, however, glucose's function as a second messenger remains relatively unexplored. Here, we find that glucose binds directly to DDX21 to regulate its func

NIAID Data Ecosystem30

Concordance of deregulated mechanisms unveiled in underpowered experiments: PTBP1 knockdown case study

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