4-1BB overexpression in basal keratinocytes induces the disruption of the eye's immune privilege. 4-1BB overexpression in basal keratinocytes induces the disruption of the eye's immune privilege

Analysis of whole transcript in mice with overexpression of 4-1BB under the control of keratin 14 promoter. The study analyze the whole transcript from all eye tissue obtained from C57/BL6 (WT control), K14-4-1BB (355) low copy number mice, K14-4-1BB (389) full blown disease mice (uveitis and cataract) and K14-4-1BB (389) onset of disease mice (eye inflammation). Overall design: Total eye tissue analyzed obtained from mice of different genetic strain: WT (C57/BL6); K14-4-1BB (355); K14-4-1BB (389) full blown disease; K14-4-1BB (389) onset of disease