Berberine mitigates 5-fluorouracil-induced intestinal mucosal damage without impairing anti-tumor effect of 5-Fu by regulating the intestinal flora

The gut microbiota plays a critical role in inflammation and colorectal cancer. However, 5-Fu led the intestinal flora disordered and induced intestinal mucositis in some studies. And previous research had revealed that BBR improved intestinal mucositis by altering the composition and abundance of intestinal flora in the mouse model. thus, to explore BBR improve 5-Fu-induced intestinal flora disorders and structural alterations