Acid-Promoted Multicomponent Tandem Cyclization to Synthesize Fully Substituted Oxazoles via Robinson–Gabriel-Type Reaction
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https://figshare.com/articles/dataset/Acid-Promoted_Multicomponent_Tandem_Cyclization_to_Synthesize_Fully_Substituted_Oxazoles_via_Robinson_Gabriel-Type_Reaction/5044846
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资源简介：
An
acid-promoted multicomponent reaction for the synthesis of diverse
fully substituted oxazole derivatives from simple and readily available
arylglyoxal monohydrates, nitriles, and various C-nucleophiles has been developed. This protocol features wide functional
group diversity which is capable of installing 4-hydroxycoumarin,
2-naphthol, and 1,3-cyclohexanedione motifs to oxazoles. Mechanistic
analysis indicates that a classical Robinson–Gabriel reaction
served as the key step for this tandem transformation.
创建时间：
2017-05-26
