Minimal dataset derived from the database.

Sheet “Baseline, age”–Gender distribution, follow-up time, age distribution of patients; derivation of average age. Sheet “New patients by year”–Number of newly identified patients in the MDD and TRD patient groups. Sheet “Mortality”–Survival curve data, OS, TRD and non-TRD patients; Cox regression results. Sheet “Comorbidities1”–Baseline characteristics of patients involved in comorbidities analysis; raw frequencies of comorbidities. Sheet “Comorbidities2”–Results of logit regression on comorbidities. Sheet “Treatment patterns”–Distribution of patients with different number of treatment ingredients for the whole study period; frequency of usage of drug classes; top 10 most commonly used antidepressants. (XLSX)