Nazarov Cyclization/Internal Redox Cyclization Sequence for the Synthesis of N‑Heterocyclic Bridged Ring Systems
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https://figshare.com/articles/dataset/Nazarov_Cyclization_Internal_Redox_Cyclization_Sequence_for_the_Synthesis_of_N_Heterocyclic_Bridged_Ring_Systems/3843849
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资源简介：
A 1,6 conjugate addition/Nazarov
electrocyclization/internal redox
cyclization sequence was developed. Various 5-hydroxycyclopentenones
were made through the 1,6-conjugate addition initiated Nazarov reaction
with excellent diastereoselectivities. Under thermal conditions, these
underwent a through-space 1,5-hydride-transfer/ring-closure reaction
to form bridged bicyclic N-heterocyclic compounds with up to four
stereogenic centers. It was also possible to convert simple acyclic
dienyl diketones into the bicyclo[3.2.1] products in a one-pot process
(with a solvent switch).
创建时间：
2016-10-03
