Single cell transcriptome profiling for hidradenitis suppurativa

Hidradenitis Suppurativa (HS) is a debilitating chronic inflammatory disease characterized by chronic abscess formation and development of multiple draining sinus tracts in the groin, axillae, and perineum. Through the use of transcriptomic approaches, we characterize the inflammatory responses in HS in depth, revealing the cell types and immune responses involved. Overall design: We conducted scRNA-seq on lesional skin from HS patients, and investigated the different disease pathways, including Hippo signaling.