The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor.
收藏Protein Data Bank Japan2024-06-26 更新2026-05-23 收录
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The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor. Descriptor: (4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one, Poly [ADP-ribose] polymerase 1, processed C-terminus Authors: Marcotte, D.J. Deposit date: 2023-09-11 Release date: 2024-03-27 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (3.02 Å) Cite: Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA-Encoded Libraries. Chemmedchem, 19, 2024
创建时间：
2023-09-11
