Asymmetric Synthesis of Spirocyclopentane Oxindoles Containing Four Consecutive Stereocenters and Quaternary α‑Nitro Esters via Organocatalytic Enantioselective Michael–Michael Cascade Reactions
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https://figshare.com/articles/dataset/Asymmetric_Synthesis_of_Spirocyclopentane_Oxindoles_Containing_Four_Consecutive_Stereocenters_and_Quaternary_Nitro_Esters_via_Organocatalytic_Enantioselective_Michael_Michael_Cascade_Reactions/7564823
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资源简介：
An enantioselective domino Michael–Michael
reaction of nitroolefins
and 2-nitro-3-arylacrylates has been established, which provided a
series of spirocyclopentane oxindoles with four consecutive stereocenters
including quaternary α-nitro esters with good yields (up to
73%) and excellent enantioselectivities (up to 97% ee). The reaction
was realized and optimized with the aid of a chiral squaramide-amine
catalyst. The structures of 11 products were confirmed by single-crystal
X-ray diffraction analysis.
创建时间：
2019-01-09
