Raw data for APP research by UniVet Internal Medicine Dept, Budapest, Hungary

Acute inflammation of the pancreas, called pancreatitis, is a common disease in humans and dogs, which can lead to severe systemic consequences. There is no standard method to predict the outcome of the disease. One possible method could be to measure blood serum acute-phase proteins, which the body produces in response to inflammation. Currently, C-reactive protein is the most commonly used acute-phase protein to monitor inflammation during pancreatitis in dogs. Still, other acute-phase proteins, such as serum amyloid A and haptoglobin, have also been suggested for use in dogs. We aimed to compare six acute-phase proteins in 10 dogs during experimental acute pancreatitis to determine the most accurate method for monitoring the disease course. Our results further support that C-reactive protein is the most useful acute-phase protein during monitoring canine acute pancreatitis; the other acute-phase proteins reflected the disease course less precisely. The measurement of serum amyloid A may have some diagnostic potential in this disease, but its role should be further investigated in spontaneous disease cases.