The top SNPs in each of the 9 sub-blocks in the UGT1A gene region (see Figure 2).

The four SNPs that are associated most significantly with serum cf-DNA levels are in sub-block 8.†For each SNP, the ancestral allele was modelled, and the β coefficient represents the change in cf-DNA level (µg/ml) with one additional copy of the ancestral allele.*Adjusted for age, sex, BMI and genetic East-West stratification in the Finnish population.Abbreviations: SNP, single nucleotide polymorphism; Chr, chromosome; bp, base pairs; MAF, minor allele frequency; S.E., standard error.