Facile Assembly of Chiral Tetrahydrothiopyrans Containing Four Consecutive Stereocenters via an Organocatalytic Enantioselective Michael–Michael Cascade

An organocatalytic enantioselective Michael–Michael cascade reaction has been implemented for the creation of structurally variant chiral tetrahydrothiopyrans. The process is realized by employment of new bifunctional ketothioether enones and proceeds highly enantioselectively with formation of four consecutive stereogenic centers.