Chemical Space of DNA-Encoded Libraries

In
recent years, DNA-encoded chemical libraries (DECLs) have attracted
considerable attention as a potential discovery tool in drug development.
Screening encoded libraries may offer advantages over conventional
hit discovery approaches and has the potential to complement such
methods in pharmaceutical research. As a result of the increased application
of encoded libraries in drug discovery, a growing number of hit compounds
are emerging in scientific literature. In this review we evaluate
reported encoded library-derived structures and identify general trends
of these compounds in relation to library design parameters. We in
particular emphasize the combinatorial nature of these libraries.
Generally, the reported molecules demonstrate the ability of this
technology to afford hits suitable for further lead development, and
on the basis of them, we derive guidelines for DECL design.