XX-650-23, an inhibitor of CREB-CBP interaction, effect on acute myeloid leukemia cell line

ChEBI2016-03-26 更新2026-07-12 收录

白血病靶向治疗

CREB-CBP通路抑制

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-74928 数据链接链接失效反馈

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XX-650-23, an inhibitor of CREB-CBP interaction, effect on acute myeloid leukemia cell line

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2016-03-26

Combined ANA and IDA treatment is an innovative and promising therapeutic strategy for AML patients with high PDE3A expression

白血病靶向治疗

药物协同作用

Acute myeloid leukemia (AML) is an invasive hematopoietic malignancy requiring novel treatment strategies. The PDE3A inhibitor anagrelide (ANA) profoundly suppresses the proliferation of high PDE3A-ex

NIAID Data Ecosystem120

Genetic and chemical targeting of the ATPase complex TIP48 and 49 impairs acute myeloid leukemia

白血病靶向治疗

ATP（三磷酸腺苷）

The chromatin-associated AAA+ ATPases Tip48 and Tip49 are the core components of various complexes implicated in diverse nuclear events such as DNA repair and gene regulation. Although they are freque

NIAID Data Ecosystem60

Amplified EPOR/JAK2 genes define a unique subtype of acute erythroid leukemia

白血病分子分型

白血病靶向治疗

Acute erythroid leukemia (AEL) is a unique subtype of acute myeloid leukemia characterized by prominent erythroid proliferation, whose molecular basis is poorly understood. To elucidate the underlying

NIAID Data Ecosystem50

A Target-Disease Network Model of Second-Generation BCR-ABL Inhibitor Action in Ph+ ALL

计算药理学

白血病靶向治疗

Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) is in part driven by the tyrosine kinase bcr-abl, but imatinib does not produce long-term remission. Therefore, second-generatio

NIAID Data Ecosystem70

A novel regulatory mechanism of U2 spliceosome proteostasis that controls the transcriptome and therapy response in cancer [RNAseq_CUTLL1_shSF3B1.2]

癌症剪接调控

白血病靶向治疗

Aberrant splicing is an important cause of cancer, and the production of noncanonical, cancer-specific, mRNA transcripts associate with transformation. Studies have focused on characterizing the effec

NIAID Data Ecosystem60

XX-650-23, an inhibitor of CREB-CBP interaction, effect on acute myeloid leukemia cell line

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