Global Time-Resolved Haplotype Dynamics of Pemivibart Escape Mutations: Frequency, Diversity, and Mutational Complexity

This dataset contains a complete, time-resolved analysis of SARS-CoV-2 spike–protein haplotypes associated probably with <b>pemivibart</b> (<b>VYD2311</b>) escape, generated from a large collection of mutation-level TSV tables. All haplotypes were reconstructed computationally and merged into a unified metadata table, followed by year-wise quantification of haplotype behavior, diversity, and mutational complexity from our earlier analysis (https://doi.org/10.6084/m9.figshare.30720401.v1).The project includes:<b>1. Haplotype reconstruction</b>Combination of all mutations per sequence into a unique haplotype stringExtraction of Year, Country, Sequence ID, and mutation countGeneration of a global haplotype table<b>2. Year-wise frequency analysis</b>Annual frequencies of all haplotypesIdentification of dominant immune-escape haplotypesEmergence ordering across 2023–2025<b>3. Shannon entropy (haplotype diversity)</b>Year-by-year computation of Shannon entropyQuantification of genetic diversity expansion within the escape ecosystem<b>4. Mutational complexity growth</b>Average, median, and maximum number of spike mutations per haplotypeTrend analysis across three years to assess complexity expansion<b>5. Compressed computational outputs</b><br>All final outputs (frequency table, entropy table, complexity table) are provided as Zstandard-compressed CSV files for efficient download and reuse.<br>This dataset supports research on antiviral escape dynamics, immune-evasion evolution, and comparative trajectory forecasting of SARS-CoV-2 spike variant clusters.<br>All files are being provided to generate all these outputs for reproducibility.Related study &amp; files are available at: https://doi.org/10.6084/m9.figshare.30720401.v1All files &amp; data is free to use with or without attribution under <b>License</b> "CC0"Comments/ Queries Welcomed!<b>Study by</b>: [e-mail]<br>