Gene database of Citrobacter rodentium ICC168

Citrobacter rodentium is a mucosal pathogen of mice, but
it shares many similarities in pathogenic mechanisms with enteropathogenic Escherichia
coli. Thus, it is a useful model for studying human gastrointestinal
diseases including Crohn’s disease. Whole-genome sequencing technologies have
been deployed in understanding the genetic repertoire endowed in C.
rodentium that results in disease. In particular, Type III secretion system
in the bacterium emerged as the major conduit for the secretion of pathogenic
effectors. This resource sought to provide the genetic repertoire of C.
rodentium ICC168 by parsing its annotated genome sequence downloaded from
Genbank. Through an in-house MATLAB software, the gene name, gene function and
gene sequence of all genes in the genome of C. rodentium are constituted
into a gene database available for download as an Excel file. Collectively, the
presented gene database should provide fundamental knowledge that could guide
efforts to postulate useful hypothesis regarding the pathogenesis mechanisms of
C. rodentium, as well as serve as the basis for genome editing efforts
to construct loss-of-function mutants for studying the effects of particular
gene in detail.