Cu-Catalyzed Remote Transarylation of Amines via Unstrained C–C Functionalization
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Remote arylation of amines via C–C bond functionalization has not been reported yet. Herein, we develop the γ-transarylation of amines through the cleavage of unstrained C–C bond enabled by copper catalysis under mild conditions, representing the example of utilization of unstrained C–C bond for metal-catalyzed C–C cross-coupling. Mechanistic investigations reveal that the redox-neutral reaction undergoes an intercepted radical pathway to cleave the Csp2–Csp3 bond, followed by the combination with copper-catalyzed arylation reaction in the presence of aryl boronic acid to construct a new Csp2–Csp3 bond.
创建时间：
2020-12-07
