Total Synthesis of the Proposed Structure of Trichodermatide A
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https://figshare.com/articles/dataset/Total_Synthesis_of_the_Proposed_Structure_of_Trichodermatide_A/2243860
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资源简介：
A short
total synthesis of the published structure of racemic trichodermatide
A is reported. Our synthesis involves a Knoevenagel condensation/Michael
addition sequence, followed by the formation of tricyclic hexahydroxanthene-dione
and a diastereoselective bis-hydroxylation. The final product, the
structure of which was confirmed by X-ray crystallography, has NMR
spectra that are very similar, but not identical, to those of the
isolated natural product. Quantum chemically computed 13C shifts agree well with the present NMR measurements.
创建时间：
2014-10-17
