Expression profiling of small, noncoding RNAs in physiologically hypertrophied rat hearts

Conclusions: This is the first report to reveal the involvement of a large number of apoptotic miRNAs during physiological cardiac hypertrophy including the previously unknown cardiac players like miR-99, miR-100, miR-191, miR-181 and miR-19. Our data indicates that regulation of these apoptotic miRNAs can be one of the major key factor in determining pathological or physiological hypertrophy by controlling apoptosis, fibrosis and cell death mechanisms.研究结论：本研究首次揭示，大量凋亡相关微小RNA（microRNA，miRNA）参与生理性心肌肥厚过程，其中miR-99、miR-100、miR-191、miR-181及miR-19等均为此前未被发现的心脏调控分子。本研究数据表明，通过调控细胞凋亡、纤维化与细胞死亡通路，对上述凋亡相关miRNA的调控可成为决定心肌肥厚为病理性或生理性的关键核心因素之一。