IMPACTS OF ALTERATIONS OF LEVEL OF GLYCOSYLATED HEMOGLOBIN IN DIABETICS ACCORDING TO PRESENCE OF CORONARY HEART DISEASE AND HYPERTENSION

Objective: To examine the
clinical impact of the alterations in the levels of glycosylated hemoglobin of diabetics
on the Chronic Heart Disease and Hypertension.

Methodology: Division of total 196 patients carried out in two
groups; control group comprising 96 patients without diabetes and patient group
with 100 diabetics. The comparison of the biochemical indexes of the patients of
both groups was carried out. Moreover, the division of the patients of the
observation group was carried out in different sub-groups in accordance with
the availability of hypertension and chronic heart disease and the comparison
of the HbA1c level was carried out in various sub-groups.

Results: There was no significant difference in the levels of
TC (Total Cholesterol), TG (Triglyceride) and LDL-C (Low-Density Lipoprotein Cholesterol)
of the patients in both groups (P>0.050). However, level of HDL-C (High Density
Lipoprotein-Cholesterol) of the patients in observational group was much low as
compared to the subjects of control group (P<0.050). SBP and DBP (Systolic
Blood Pressure and Diastolic Blood Pressure), FPG (Fasting Plasma Glucose), FI
(Fasting Insulin) and values of hs-CRP (High-Sensitivity C - reactive protein)
and level of HbA1c of patients in observational group were significantly high
in comparison with the group of controls (P<0.050). HbA1c level of the hypertension
patients was much higher as compared to the patients without hypertension (P<0.050).
HbA1c level of the patients suffering from chronic heart disease was
significantly higher as compared to the patients without chronic heart disease (P<0.050).
The results of the Pearson correlation analysis stated that HbA1c level of the patients
in group of diabetics was in strong correlation with systolic and diastolic
blood pressures and CRP level (P<0.050).

Conclusion: HbA1c level of the patients suffering from diabetes
was in a strong association with the blood pressure and CRP level. HbA1c level can
predict the rate of occurrence of hypertension and chronic heart disease. Identification
of the values of glycosylated hemoglobin is much vital in the screening of the
patients present with hypertension and chronic heart disease.

KEY WORDS: Diabetics, Blood Pressure, Hba1c, Hypertension,
Chronic Heart Disease, Systolic, Diastolic, Plasma, Fasting Plasma Glucose.