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Structure of FPT bound to the inhibitor SCH66336

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Protein Data Bank Japan2023-12-27 更新2026-03-21 收录
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Structure of FPT bound to the inhibitor SCH66336 Descriptor: 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, FARNESYL DIPHOSPHATE, Protein farnesyltransferase alpha subunit, ... Authors: Strickland, C.L, Weber, P.C, Ganguly, A.K. Deposit date: 2003-09-26 Release date: 2003-10-21 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Tricyclic Farnesyl Protein Transferase Inhibitors: Crystallographic and Calorimetric Studies of Structure-Activity Relationships J.Med.Chem., 42, 1999
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2003-09-26
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