Epigenetic inflexibility of exhausted T cells limits durability of reinvigoration by PD-1 blockade

Upon PD-1 pathway blockade,the epigenetic landscape of exhausted cells was only minimally remodeled consistent with lineage commitment and re-exhaustion of these cells over time. Overall design: Epigenetic profiling of Exhausted T cells & examinaton of epigenetic changes associated with PD-pathway blockade by ATAC-seq using the mouse model of chronic infection with lymphocytic choriomeningitis virus (LCMV)