Impact of normal tissue-specificity on comparative analysis of liver cancer and glioblastoma.

The table lists the 10 MSigDB Hallmark pathways most significantly associated with relative gene expression between liver and cerebral cortex and between liver cancer and glioblastoma. Gene set testing of cancer relative expression was performed using all genes (middle column) and using genes filtered according to normal tissue differential expression (right column). Filtering specifically removed all genes whose log2 fold-change in expression between liver and cerebral cortex was ≤−2 or ≥2. Without filtering, differential gene expression between liver cancer and glioblastoma is similar to differential expression between normal liver and cerebral cortex.