Single-cell RNA-sequencing of human vascular and tissue innate lymphoid cells (ILCs) in the spleen of MISTRG humanized mice

The migratory properties of human ILCs are poorly understood. In this study, we mapped at single-cell resolution the heterogeneity and spatial compartmentalization of human ILCs in the spleen, using an in-vivo model (MISTRG humanized mice) for human ILCs. We used intravascular cell labeling in combination with single-cell RNA-sequencing to define the gene signatures of human ILCs in the vascular and tissue compartment of MISTRG mice engrafted with human CD34+ hematopoietic stem and progenitor cells (HSPCs). **As Swedish legislation and GDPR prevent unrestricted distribution of raw sequencing data, raw sequence data cannot be provided, including through controlled access databases.***