Correlations of HHEX SNPs rs1111875 and rs7923837 with insulin sensitivity and insulin secretion.

For statistical analysis, data were log-transformed. Plasma glucose levels and indices of insulin sensitivity were adjusted for gender, age, and BMI. Indices of insulin secretion were adjusted for gender, age, BMI, and ISI (OGTT). p1 – unadjusted; p2 – adjusted, additive model; p3 – adjusted, dominant model. AUC – area under the curve; HOMA-IR – homeostasis model assessment of insulin resistance; ISI – insulin sensitivity index; MAF – minor allele frequency; SNP – single nucleotide polymorphism. *subgroup (N = 491).