Mutations in enzymes critical for glycosphigolipid (GSL) biosynthesis are defective in Sma/Mab signaling.

Animals were growing at 20°C and scored at the L4 stage except for cgt-3(ok2877)* animals, which were arrested at late L1/early L2, and for the cold-sensitive pod-2(ye60)** animals which were growing at 15°C during postembryonic development. ***p<0.0001, cgt-3(ok2877); jjEx[hlh-8p::cgt-3] versus cgt-3(ok2877) worms (unpaired two-tailed Student’s t-test). a The sma-9 gene product is not listed in this column. b Data generated by averaging the results from three independent transgenic lines. Mutations in enzymes critical for glycosphigolipid (GSL) biosynthesis are defective in Sma/Mab signaling.