Diurnal salivary androstenedione and 17‐hydroxyprogesterone levels in healthy volunteers

This dataset corresponds to the article ‘Diurnal salivary androstenedione and 17-hydroxyprogesterone levels in healthy volunteers for monitoring treatment efficacy of patients with congenital adrenal hyperplasia’ (DOI: 10.1111/cen.14690) published in Clinical Endocrinology (Clin Endo).

This study aimed to establish age-adjusted reference values for salivary androstenedione and 17-hydroxyrprogesterone. We wanted to get insight into the diurnal variation of these adrenal steroids in the heatlhy population and therefore measured these hormones in saliva that was collected in the morning, afternoon, and evening. For this dataset, we used saliva of healthy volunteers from schools in Nijmegen, the Netherlands and also asked (grand)parents / caregivers of these children to collected saliva at these times to enable inclusion of volunteers with a broad age range. With this data set, age-adjusted reference values for these three time points could be established.

The attached file contains the raw data used for conducting this study. For each participant the sex, menstruation status, and age (in years) are given. Thereafter, the time of saliva collection is given in a 24-hour data notation for the morning, afternoon, and evening. Then, the androstenedione and 17-hydroxyprogesterone levels (in pmol/L) are given for the morning, afternoon, and evening samples. If the concentration of the measured steroid was below the lower limit of quantification (LLOQ) and the signal-to-noise ratio was <10, the value was assigned half of the LLOQ. The LLOQ for androstenedione is 7 pmol/L, and for 17-hydroxyprogesterone 20 pmol/L.