Synthesis of nascent polypeptide containing signal sequence

The synthesis of a protein destined for the endoplasmic reticulum starts with the canonical events of cytosolic translation initiation and proceeds to the point where a nascent polypeptide chain containing a signal sequence protrudes from the mRNA:ribosome complex. Merrick (2010) provides an overview of these events.蛋白质合成过程旨在靶向内质网，其起始环节为细胞质翻译起始的典型事件，并延续至新生多肽链携带信号序列从mRNA:核糖体复合物中伸出之际。Merrick（2010）对这些事件进行了概述。