Human BM-MSC and BM-neurosphere transplantation shows limited efficacy as a therapeutic adjunct to surgical decompression in an implantable polymer-induced DCM model.

Human bone marrow-derived marrow stromal cell (BM-MSC) and neurosphere (BM-neurosphere) transplantation shows limited efficacy as a therapeutic adjunct to surgical decompression in an implantable polymer-induced degenerative cervical myelopathy (DCM) model Degenerative cervical myelopathy (DCM) is a prevalent spinal cord disorder in the developed world. The study investigates the therapeutic potential of human bone marrow-derived mesenchymal stem cells (BM-MSC) and BM-neurospheres as adjunct therapies to surgical decompression in a polymer-induced DCM rat model. The study assessed locomotor function, blood-spinal cord barrier (BSCB) integrity, and cell engraftment. Results showed delayed locomotor recovery upon cervical decompression and limited efficacy of BM-MSCs and BM-neurospheres in improving outcomes under the experimental conditions. Overall design: RNAseq on hBM-MSC (n=3) and hBM-neurospheres (n=3) from cultured from three bone marrow donors