Multi-Omics Mapping of Gut Microbiota's Role in Progesterone Metabolism

The microorganisms in the human gut can convert progesterone into several neurologically active steroids.Pregnanolone was identified as the primary metabolite produced when gut microbes metabolize progesterone.Members of the bacterial families Enterobacteriaceae and Veillonellaceae play key roles in pregnanolone production.Genes involved in pregnanolone production are prevalent in bacterial genomes from Enterobacteriaceae and Veillonellaceae.The abundances of Enterobacteriaceae and Veillonellaceae differ significantly among healthy women and women who experienced recurrent miscarriage.