Influence of the Muc1 on Gene Expression Profiles in Helicobacter Pylori Infection in Mice

The cell surface mucin MUC1 is an important host factor limiting Helicobacter pylori (H. pylori) pathogenesis in both humans and mice by providing a protective barrier and modulating mucosal epithelial and leukocyte responses. We used microarrays to detail the global programme of gene expression in Wild type and MUC1- deficient mice in response to H. pylori infection. We elucidate the time-course of molecular events and dynamic networks in gastric tissue from Muc1-/- and wild type (WT) mice in response to the very early stages of H. pylori infection.