Mean accuracy of imputation (r2 of allelic dosage across all samples for a SNP) averaged across SNPs split by Minor Allele Frequency (MAF).

MAF bins increase by factors of √10, to create four exponentially increasing bins.N SNPs: number of SNPs in MAF bin.1kG: 1000 Genomes used as reference panel.1kG+LRP: 1000 Genomes plus local reference panel.Increase r2: Average across all SNPs in MAF bin increase in r2.Std dev: The standard deviation (across SNPs) of the increase in r2 at each SNP.Inc. Sample: Increase in effective sample size for GWAS.The standard errors of mean increases are less than 0.003. All improvements in r2 are significantly different from zero and significantly different between MAF bands (P