effects of phloretin therapy on water and glucose transport during experimental peritoneal dialysis: a dose-response study

Unwanted glucose absorption remains a major drawback of peritoneal dialysis treatment. Recently we found that phloretin, a non-selective blocker of faciltative glucose channels (GLUTs), acts to reduce glucose absorption thereby improving osmotic water removal during peritoneal dialysis. Experimental peritoneal dialysis was conducted on fifty healthy Sprague-Dawley rats. The animals were exposed to glucose-based dialysis fluid containing five different concentrations of phloretin. To determine the plasma-to-dialysate transport, we used radiolabeled 18F-deoxyglucose., , , # Data from: effects of phloretin therapy on water and glucose transport during experimental peritoneal dialysis: a dose-response study GENERAL INFORMATION 1. Title of Dataset: Dose-Response Relationship Between Intra-peritoneal Phloretin Therapy and Water and Glucose Transport during Peritoneal Dialysis in Sprague-Dawley rats 2. Author Information A. Principal Investigator Contact Information Name: Carl Öberg Institution: Lund University, Medical Faculty Address: Box 117, SE-221 00 Email: [[e-mail]](mailto:[e-mail]) 3. Date of data collection June 2022 to September 2023 4. Geographic location of data collection: Lund, Sweden 5. Information about funding sources that supported the collection of the data: Funding by the Crafoord Foundation, Lund University Medical Faculty Foundation grant YF 2020-YF0056, and The Inga-Britt and Arne Lundberg’s Research Foundation (all to C.M. Öberg). SHARING/ACCESS INFORMATION 1. Licenses/restrictions placed on t...