A lysosomal regulatory circuit essential for the development and function of microglia

We performed Illumina NovaSeq on zebrafish larvae with or without Zymosan A injection Zymosan A was injected into wildtype animals and tfeb; tfe3a; tfe3b triple mutants to examine the extent to which Tfeb and Tfe3 activate lysosomal pathways in response to inflammatory challenge. rraga mutant larvae were included in the experiment for comparison.