Neuregulin-1β augments adaptive concentric remodeling and systolic function without exacerbating hypertrophy during pressure-overload

The study compares three groups of mice one week after pressure overload induced by transverse aortic constriction (TAC) or control (sham) surgery. Comprehensive echocardiographic datasets are provided in supplementary tables, including male mice assessed at 1 week (Table S1) and up to 4 weeks (Table S2) after surgery, as well as female mice assessed at 1 week (Table S3). The accompanying XLSX file contains complete lists of differentially expressed genes identified through bioinformatic analysis of the RNA-sequencing data. Supplementary Figure S1 presents volcano plots and pathway analyses of genes differentially expressed among experimental groups. Supplementary Figure S2 highlights 23 genes that were differentially expressed both between neuregulin-1β (NRG1)–treated TAC mice and saline-treated TAC controls, and between NRG1-treated TAC mice and sham controls. Supplementary Figure S3 reports results from an additional experiment using intermittent NRG1 administration via daily intrape..., , # Data from: Neuregulin-1β augments adaptive concentric remodeling and systolic function without exacerbating hypertrophy during pressure-overload Dataset DOI: [10.5061/dryad.7m0cfxq8s](https://doi.org/10.5061/dryad.7m0cfxq8s) ## Description of the data and file structure This dataset comprises RNA-sequencing data, three supplementary figures, and five supplementary tables associated with the manuscript *“Neuregulin-1β Augments Adaptive Concentric Remodeling and Systolic Function Without Exacerbating Hypertrophy During Pressure Overload”* by Xu *et al*.\ \ Xu_Supplemental_Figures.pdf: Supplemental Figures S1, S2, and S3\ Xu_Supplemental_Tables.pdf: Supplemental Tables S1 to S5\ Both .pdf files can be opened using Acrobat Reader. Xu_Supplemental_Data_RNAseq.xlsx: \ The XLSX file contains lists of differentially expressed genes for three pairwise comparisons between experimental groups (p < 0.01 and FDR < 0.2). The first worksheet presents the comparison between male sham and TAC grou...,