UCD Imaging Study

This is a case controlled, observational study. This project studies cognitive and motor dysfunction in adult and pediatric patients who are female carriers of ornithine transcarbamylase deficiency (OTCD) or are males with late onset presentation (outside of the newborn period) of OTCD, utilizing state of the art MRI (magnetic resonance imaging), a non-invasive technique. This project seeks to improve our understanding of the underlying neural mechanisms that contribute to metabolic, cognitive, sensory and motor abnormalities in urea cycle disorders, which although individually rare, collectively constitute a major cause of neonatal encephalopathy, leading to significant morbidity and mortality. As a result of this study, a greater understanding of the anatomic, cognitive, motor, and biochemical underpinnings of neurologic damage attributable to this metabolic disorder will be gained. Experimental approaches will combine sensory, cognitive and motor testing with structural, functional and molecular magnetic resonance imaging to study symptomatic and asymptomatic heterozygous female carriers of X-linked ornithine transcarbamylase deficiency (OTCD), and late onset hemizygous males. Participants to be included in the studies ranged from ages 7-60 years and were compared to an age-matched typically developed (TD) comparison group. For our research, we use anatomic MRI, functional Magnetic Resonance Imaging (fMRI), and magnetic resonance spectroscopy (MRS) to monitor brain activity. The technique of fMRI provides detailed maps of the brain areas underlying human mental activities. By using fMRI, we are able to observe how the brain is functioning while a person is performing a specific task, such as reading. We can not only observe differences in the structure of the brain, but can also measure differences in brain function and activity as well. This information will ultimately be used to provide a basis for designing more effective interventions and methods for early identification of learning disabilities in patients with OTCD and related disorders. We will also use MRS to study various brain chemicals such as glutamine using the non-invasive MRI imaging techniques. ]]> UCDC 5107: Demographic Information FormUCDC 5107: Eligibility FormUCDC 5107: Laboratory FormUCDC 5107: Neuropsychological Testing FormUCDC 5107: Physical and Neurological Exam FormUCDC 5107: Pregnancy Screening FormUCDC 5107: History and Review of Medical RecordsConclusion of Study ParticipationSubject inclusion criteria: Patients with OTCD; Age range: 7-60 years Able to undergo neuroimaging safely (i.e. without presence of ferromagnetic devices) Subject has a documented full scale IQ > 70 Subject exclusion criteria: Mental retardation (i.e., Full Scale IQ< 70) Age range <7 or >60 years Presence of ferromagnetic device(s) that preclude safe imaging Pregnant female Control participant inclusion criteria: Healthy males and females without metabolic disease aged 7-60 years Subject has a documented full scale IQ > 70 Control exclusion criteria: Subjects with a documented history of an intellectual deficit (i.e., Full Scale IQ< 70) Age range <7 or >60 years Presence of ferromagnetic device(s) that preclude safe imaging Pregnant female ]]> Study Activated September 12, 2010 First Accrual October 4, 2010 Last DSMB review December 1, 2014 Next DSMB review scheduled for January 12, 2016 Study Closed to Accrual in data analysis on November 18, 2014 ]]>