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DdCBE-mediated mitochondrial base editing in human 3PN embryos. Homo sapiens

NIAID Data Ecosystem2026-03-12 收录

线粒体基因编辑

人类胚胎研究

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA758365 数据链接链接失效反馈

官方服务：

资源简介：

Sequence Data human embrys microinjected using DdCBE

应用场景：

创建时间：

2021-08-27

线粒体基因编辑

基因敲除小鼠

We design and apply a highly optimized library of double-stranded DNA deaminase (DddA)-derived cytosine base editors (DdCBEs) - MitoKO - to precisely ablate every mtDNA protein coding gene in the mous

NIAID Data Ecosystem70

Enhanced DdCBE with NES and mitoTALEN

线粒体基因编辑

基因治疗

Enhanced DdCBE for m.G12918A in mice with NES and mitoTALEN.

NIAID Data Ecosystem60

Predictability of DdCBEs mediated base editing in mitochondrial DNA

线粒体基因编辑

碱基编辑优化

DdCBE acts as the most commonly used editor for mtDNA, our understanding of the editing rules is very limited, especially for the aC targets, we need to optimize the editing strategies by adjusting th

NIAID Data Ecosystem40

Annual returns for research involving human embryos

人类胚胎研究

年度数据

Annual return of data from centres who have research projects that involve the use of human embryos

data.gov.uk2013-08-30 更新70

Knockout of CMS-causative mitochondrial gene. Oryza sativa

水稻细胞质雄性不育

线粒体基因编辑

To determine whether a mitochondrial gene orf312 causes Tadukan-type cytoplasmic male sterility using mitochondrial-targeted TALEN

NIAID Data Ecosystem60