Differences of actionable genomic alterations between brain metastases and non-brain metastases in Chinese patients with non-small cell lung cancer. Homo sapiens

In this study, we carried out targeted next-generation sequencing (NGS) of tumor tissues and peripheral blood samples from NSCLC patients by a hybridization capture-based panel. The differences in somatic mutations, somatic interactions, key signaling pathways, functional biological information, and clinical actionability for the therapy of targeted agents were explored between advanced patients with and without brain metastases.