Herbs, ingredients and targets of SWT and SJZT1.rar

Traditional Chinese Medicine (TCM) is
increasingly getting clinical application worldwide. But its theory like
QI-Blood is still abstract. Actually, Qi deficiency and blood deficiency, which
were treated by Si-Jun-Zi-Tang (SJZT) and Si-Wu-Tang (SWT) respectively, have characteristic
clinical manifestations. Here, we analyzed targets of the ingredients in SJZT
and SWT to unveil potential biologic mechanisms between Qi deficiency and blood
deficiency through biomedical approaches. First, ingredients in SWT and SJZT
were retrieved from TCMID database. The genes targeted by these ingredients
were chosen from STITCH. After enrichment analysis by Gene Ontology (GO) and DAVID,
enriched GO terms with p-value less than 0.01 were collected and interpreted
through DAVID and KEGG. Then a visualized network was constructed with ClueGO. Finally,
a total of 243 genes targeted by 195 ingredients of SWT formula and 209 genes
targeted by 61 ingredients of SJZT were obtained. Six

metabolism pathways and two environmental information
processing pathways enriched by targets were correlated with two or more
herbs in SWT and SJZT formula, respectively. SWT significantly influence
amino acid and carbohydrate metabolism. While SJZT mainly influence the organismal
system function, environmental information processing, metabolism and cellular
processes.