Dinuclear Tridentate Ru(II) Complex with Strong Near-Infrared Light-Triggered Anticancer Activity
收藏NIAID Data Ecosystem2026-05-02 收录
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https://figshare.com/articles/dataset/Dinuclear_Tridentate_Ru_II_Complex_with_Strong_Near-Infrared_Light-Triggered_Anticancer_Activity/26081846
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资源简介：
The
design of the dinuclear Ru(II) complex (Ru2) with
strong near-infrared (NIR) absorption properties has been reported
for efficient anticancer phototherapy. Under 700 nm LED light excitation, Ru2 exhibited remarkable synergistic type I/II photosensitization
ability and photocatalytic activity toward intracellular biomolecules. Ru2 showed impressive 700 nm light-triggered anticancer activity
under normoxia and hypoxia compared with the clinically used photosensitizer
Chlorin e6. The mechanistic studies showed that Ru2 induced
intracellular redox imbalance and perturbed the energy metabolism
and biosynthesis in A549 cancer cells. Overall, this work provides
a new strategy for developing efficient metal-based complexes for
anticancer phototherapy under NIR light.
创建时间：
2024-06-21
