Actinoallolides A–E, New Anti-trypanosomal Macrolides, Produced by an Endophytic Actinomycete, Actinoallomurus fulvus MK10-036

Five
new anti-trypanosomal macrolides, actinoallolides A–E
(1–5), were discovered from the cultured
broth of Actinoallomurus fulvus MK10-036.
The structures of the actinoallolides, including absolute stereochemistry,
were elucidated by a combination of spectroscopic analyses and a series
of chemical derivatization studies. Actinoallolide A showed the most
potent and selective in vitro anti-trypanosomal activity without cytotoxicity.
A new class of promising lead compounds was identified for the development
of drugs for both sleeping sickness and Chagas disease.