Abstract The IgG4-related disease has a wide clinical spectrum where multiple organs can be affected, and the diagnosis depends on typical histopathological findings and an elevated IgG4 expression in
This study aims to investigate the gut microbiome alterations in IgG4-related ophthalmic disease (IgG4-ROD) and explore the potential roles of serum IgE and IgG4 in this disease.
We identified 36 genes showing ≥3-fold increase or decrease in expression in IgG4-RD patients in response to steroid therapy. IFI44L, SNORA42 and HIST1H2BB had decreased expression by steroid therapy,