RNA-seq analysis of angiotensin II-induced myocardial fibrosis in rats treated with and without sodium butyrate

Analysis of sodium butyrate(NaBu) on angiotensin II(Ang II-induced cardiac fibrosis at gene expression level. The hypothesis tested in the present study was that NaBu influence the balance of gene expression of Ang II-induce cardiac fibrosis. Results provide important information of the response of NaBu to cardiac fibrosis, such as specific genes, up- or down-regulated specific cardiac cellular functions. Overall design: Total RNA obtained from isolated tendon fascicles subjected to 1 or 24 hours in vitro cyclic tensile strain compared to unstrained control fascicles.