Differences in bacterial taxa between treatment-naive patients with major depressive disorder and non-affected controls may be related to a proinflammatory profile. human gut metagenome

Illumina amplicon sequencing of the V4 hypervariable region of the 16S rRNA gene. Samples consists of feces obtained from adults with major depressive disorder (MDD) and non-depressed controls. The purpose of the study was to compare the gut microbiota and systemic inflammatory profile of young patients with MDD before and after initiation of antidepressant treatment and/or psychotherapy in comparison with a non-depressed control group.