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Human cells transcription fidelity - RNAP mutants and exposure to MNNG

NIAID Data Ecosystem2026-03-14 收录

转录保真度分析

聚合酶突变效应

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP417491 数据链接链接失效反馈

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资源简介：

Rolling-circle RNAseq data used to estimate transcription fidelity of human cells with several RNA polymerase mutants and for cells exposed to MNNG.

应用场景：

创建时间：

2023-01-15

噬菌体疗法机制

聚合酶突变效应

We use Illumina sequencing to monitor mutations in the bacteriophage T7 genome in the presence of T7 DNA polymerase that has an altered exonuclease active site. These alterations include mutation of k

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Mutation of rpoB shifts the nutrient threshold triggering Myxococcus multicellular development

干细胞发育调控

聚合酶突变效应

The ability to perceive and respond to environmental change is essential to all organisms. In response to nutrient depletion, cells of the soil-dwelling δ-proteobacterium Myxococcus xanthus undergo co

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Active site of cyanobacterial RNA polymerase compensates for the absence of proofreading factors [Synechoscystis sp]

转录保真度分析

细菌遗传学

We found that cyanobacterial RNA polymerase possesses very efficient intrinsic proofreading ability. This ability allows model species of cyanobacteria, Synechocystis sp PCC 6803 to keep in vivo level

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An RNA Polymerase Ribozyme that Synthesizes its Own Ancestor

核酶进化

聚合酶突变效应

As part of an examination of a newly-evolved RNA polymerase ribozyme, 38-6, products of primer extension experiments using an RNA template encoding the hammerhead RNA endonuclease ribozyme, using 38-6

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RNA polymerase persistence mutations

细菌耐药性机制

聚合酶突变效应

Individual bacteria can escape killing by bactericidal antibiotics by becoming dormant. Such cells, also known as persisters, naturally occur in bacterial populations at a low frequency. Guided by the

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Human cells transcription fidelity - RNAP mutants and exposure to MNNG

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