The binding free energy and energy components (kcal/mol) for the four HLA/MICA-TM complexes predicted by the MM/PBSA method.

HLA alleles area associated orb not associated with Behçet’s disease (BD).Data are shown as the mean ± SD, derived from independent simulations. Means within a paired row (HLA-A or HLA-B alleles that are associated with BD versus that are not) followed by a different letter are significantly different.ΔGbind is the binding energy with inclusion of entropic term.The binding free energy and energy components (kcal/mol) for the four HLA/MICA-TM complexes predicted by the MM/PBSA method.