The structure of ERK2 in complex with dual inhibitor ASTX029
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The structure of ERK2 in complex with dual inhibitor ASTX029 Descriptor: (2~{R})-2-[5-[5-chloranyl-2-(oxan-4-ylamino)pyrimidin-4-yl]-3-oxidanylidene-1~{H}-isoindol-2-yl]-~{N}-[(1~{S})-1-(3-fluoranyl-5-methoxy-phenyl)-2-oxidanyl-ethyl]propanamide, DIMETHYL SULFOXIDE, Mitogen-activated protein kinase 1, ... Authors: O'Reilly, M. Deposit date: 2020-11-03 Release date: 2021-10-06 Last modified: 2024-11-06 Method: X-RAY DIFFRACTION (1.76 Å) Cite: ASTX029, a Novel Dual-mechanism ERK Inhibitor, Modulates Both the Phosphorylation and Catalytic Activity of ERK. Mol.Cancer Ther., 20, 2021
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2020-11-03
