The mechanism of palmatine-mediated intestinal flora and host metabolism intervention in OA-OP comorbidity rats

ErXian decoction is a Chinese herbal compound that can prevent and control the course of osteoarthritis and osteoporosis . OP and OA are two age-related diseases that often coexist in elderly individuals, and both are associated with dysregulation of the gut microbiome. In preliminary work, palmatine was obtained by liquid chromatography with tandem mass spectrometry and network pharmacological screening. In this study, 16S rRNA sequencing and metabolomics were used to investigate the mechanism of PAL in the treatment of OA and OP.